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Title of Journal : Chinese Chemical Letters  Author : Dong Hui Yang  C_Author : Shao Qing Cai  Year : 2004  Volume No. : 14  Issue No. : 7  Page No. : 233-236  
Title of Journal : Anticancer Research  Author : Andreas Wirge  C_Author : Frank Perabo G.E.  Year : 2005  Volume No. : 25  Issue No. : 6(B)  Page No. : 4341-4347  
Title of Journal : Journal of Chemical and Pharmaceutical Research  Author : Shankaracharya.  C_Author : Priyamvada and Vidyarthi,A.S.  Year : 2010  Volume No. : 2  Issue No. : 3  Page No. : 329-337  
Title of Journal : Molecular Cancer Therapeutics  Author : Michelle Alonso  C_Author : Cristina Tamasdan  Year : 2003  Volume No. : 2  Issue No. :   Page No. : 139-150  
Title of Journal : Molecular pharmacology  Author : Yasunari Takada  C_Author : Gautam Sethi  Year : 2008  Volume No. : 73  Issue No. : 5  Page No. : 1549 - 1557  
Title of Journal : The Journal of Biological Chemistry  Author : Yasunari Takada  C_Author : Bharat Aggarwal B.  Year : 2004  Volume No. : 279,  Issue No. : 6,  Page No. : 4750 - 4759  
Title of Journal : Cancer Research  Author : Bible K.C.  C_Author : Kaufmann S.H.  Year : 1996  Volume No. : 56  Issue No. : Nov  Page No. : 4856-4861  
Title of Journal : Blood journal. Hematology Library.org  Author : Francisco Arguello  C_Author : Mark Alexander  Year : 1998  Volume No. : 91  Issue No. : 7  Page No. : 2482-2490  
Title of Journal : Journal of Pharmacological Sciences  Author : Katsuji Hattori  C_Author : Naoe Sukenobu  Year : 2003  Volume No. : 93  Issue No. :   Page No. : 69-73  
Title of Journal : Haematologica  Author : William Blum  C_Author : Mitch Phelps A.  Year : 2010  Volume No. : 95  Issue No. : 7  Page No. : 1097-1105  
Title of Journal : Current Opinion in Pharmacology  Author : Adriana B da Rocha  C_Author : Rafael Lopes M.  Year : 2001  Volume No. : 1  Issue No. :   Page No. : 364 - 369  
Title of Journal : Oncogene  Author : Adrian Senderowicz M.  C_Author :   Year : 2000  Volume No. : 19  Issue No. :   Page No. : 6600-6606  
Title of Journal : Journal of Ethnopharmacology  Author : Tomonori Unno  C_Author : Akio Sugimoto  Year : 2004  Volume No. : 93  Issue No. : 1  Page No. : 391-395  
Title of Journal : Oncogene  Author : Mirna Lechpammer  C_Author : Xiangjun Xu  Year : 2005  Volume No. : 24  Issue No. :   Page No. : 1683-1688  
Title of Journal : Ann. appl. Biol  Author : Cragg G.M.  C_Author : Newman D.J.  Year : 2003  Volume No. : 143  Issue No. :   Page No. : 127-133  
Title of Journal : Ann. appl. Biol  Author : Cragg G.M.  C_Author : Newman D.J.  Year : 2003  Volume No. : 143  Issue No. :   Page No. : 127-133  
Title of Journal : Indian journal of Experimental Biology  Author : Kamlesh Bhutani K.  C_Author : Vikrantsinh Gohil M.  Year : 2010  Volume No. : 48  Issue No. :   Page No. : 197-207  
Title of Journal : Medicinus  Author : Florensia Nailufar  C_Author : Raymond R  Year : 2011  Volume No. : 24  Issue No. : 1  Page No. : 13-17  
Title of Journal : Journal of Ethnopharmacology  Author : Cragg Gordon M.  C_Author : Newman David J.  Year : 2005  Volume No. : 100  Issue No. :   Page No. : 72-79  
Title of Journal : Indian Journal of Experimental Biology  Author : Aswal S.  C_Author : Goel A.K.  Year : 1996  Volume No. : 34  Issue No. :   Page No. : 444-467  
Title of Journal : The Scientific World  Author : Perez G.R.M.  C_Author :   Year : 2001  Volume No. : 1  Issue No. :   Page No. : 713-784  
Title of Journal : Invest New Drugs  Author : Diaz Padilla I.  C_Author : Lillian Siu L.  Year : 2009  Volume No. : 27  Issue No. :   Page No. : 586-594  
Title of Journal : Thesis  Author : Tanja Pies  C_Author : Herrn PD, Dr.Kunick C.  Year : 2003  Volume No. :   Issue No. :   Page No. : 325  
Title of Journal : Current Opinion Pharmacol.  Author : Dai Y.  C_Author : Grant S.  Year :   Volume No. :   Issue No. :   Page No. :   
Title of Journal : Phytochem Review  Author : Cragg G.M.  C_Author : Newman D. J.  Year : 2009  Volume No. : 8  Issue No. :   Page No. : 313-331  
Title of Journal : Cancer Chemother Pharmacol  Author : Senderowicz AM.  C_Author :   Year : 2003  Volume No. : 52  Issue No. : 1  Page No. : 61-73  
Title of Journal : Ethno medicine in complementary therapeutics  Author : Pulok Mukherjee K.  C_Author : Ponnusankar S.  Year : 2010  Volume No. :   Issue No. :   Page No. : 29-52  
Title of Journal : Diabetes Research and Clinical Practice  Author : Judy William V.  C_Author : Hari Siva P.  Year : 2006  Volume No. : 87  Issue No. : 1  Page No. : 115-117  
Title of Journal : International Journal of Pharmaceutical Research and Development  Author : Pritikumari Lad N.  C_Author : Nisarg Patel C.  Year : 2011  Volume No. : 3  Issue No. : 6  Page No. : 110-117  
Title of Journal : Human Medicinal Agents from Plants  Author : Noel de Souza J.  C_Author :   Year : 1993  Volume No. : Chapter 22  Issue No. :   Page No. : 331-340  
Title of Journal : Opportunity, Challenge and Scope of Natural Products in Medicinal Chemistry  Author : Bhuwan Mishra B.  C_Author : Vinod Tiwari K.  Year : 2011  Volume No. :   Issue No. :   Page No. : 1-62  
Title of Journal : Book-Molecular biology intelligence unit 15  Author : Blagosklonny Mikhail V.  C_Author :   Year : 2001  Volume No. : Chapter-13  Issue No. :   Page No. : 1-267  
Title of Journal : Anti-Cancer Drugs  Author : Newcomb  C_Author : Elizabeth W.A  Year :   Volume No. : 15  Issue No. : 5  Page No. : 411-419  
Title of Journal : Cell Proliferation  Author : Katrien Vermeulen  C_Author : Van Bockstaele Dirk R.  Year : 2003  Volume No. : 36  Issue No. :   Page No. : 131-149  
Title of Journal : Cancer Res Treat.  Author : Suzy Kim  C_Author : Hong-Gyun Wu  Year : 2005  Volume No. : 37  Issue No. : 3  Page No. : 191-195  
Title of Journal : Oncology NEWS International  Author : Schwartz Gary K.  C_Author :   Year : 2002  Volume No. : 11  Issue No. : 5  Page No. : 1-3  
Title of Journal : Thesis submitted for the degree of Doctor of Philosophy at the University of Leicester  Author : Anthony James Wilson BSc  C_Author :   Year : 2008  Volume No. :   Issue No. :   Page No. :   
Title of Journal : Molecular pharmacology  Author : Ning Gao  C_Author : Yun Dai  Year : 2004  Volume No. : 66  Issue No. : 4  Page No. : 956-963  
Title of Journal : Tetrahedron  Author : Ramachandra Naik G.  C_Author : Kattige S.L.  Year : 1988  Volume No. : 44  Issue No. : 7  Page No. : 2081-2086  
Title of Journal : Clin Cancer Res  Author : Smith Melissa E.  C_Author : Velasco Cimica  Year : 2008  Volume No. : 14  Issue No. : 2  Page No. : 523-532  
Title of Journal : The Oncologist  Author : Elsayed Yusri A.  C_Author : Sausville Edward A.  Year : 2001  Volume No. : 6  Issue No. :   Page No. : 517-537  
Title of Journal : The British Journal of Radiology  Author : Nitta N.  C_Author : Sonoda A.  Year : 2010  Volume No. : 83  Issue No. :   Page No. : 428-432  
Title of Journal : International Journal of Biomedical Research  Author : Talha Jawaid  C_Author : Deepa Shukla  Year : 2011  Volume No. : 2  Issue No. : 4  Page No. : 252?263  
Title of Journal : J. Agric. Food Chem  Author : Naisheng Bai  C_Author : Kan He  Year : 2008  Volume No. : 56  Issue No. : 24  Page No. : 11668-11674  
Title of Journal : Expert Opinion on Investigational Drugs  Author : Lloyd R Kelland  C_Author :   Year : 2000  Volume No. : 20  Issue No. : 9  Page No. : 2903-2911  
Title of Journal : Drug metabolism and disposition  Author : Birgit Hagenauer  C_Author : Alexandra Salamon  Year : 2001  Volume No. : 29  Issue No. : 4(1)  Page No. : 407-414  
Title of Journal : Clin Cancer Res  Author : Christina Richard  C_Author : Donald Matthews  Year : 2005  Volume No. : 11  Issue No. : 9  Page No. : 3523-3529  
Title of Journal : Experimental Biology and Medicine  Author : Subash Gupta C  C_Author : Ji Hye Kim  Year : 2011  Volume No. :   Issue No. :   Page No. : 1-14  
Title of Journal : Pakistan journal of Biological Sciences  Author : Haque N.  C_Author : Salma U.  Year : 2001  Volume No. : 14  Issue No. : 1  Page No. : 13-24  
Title of Journal : Pure Appl. Chem  Author : Cragg Gordon M.  C_Author : Michael Boyd R.  Year : 1999  Volume No. : 71  Issue No. : 9  Page No. : 1619-633  
Title of Journal : Molecular Cancer Therapeutics  Author : Rosato Roberto R.  C_Author : Almenara Jorge A.  Year : 2002  Volume No. : 1  Issue No. :   Page No. : 253-266  
Title of Journal : Clin Cancer Res  Author : Judith Karp E.  C_Author : Douglas Smith B.  Year : 2007  Volume No. : 13  Issue No. : 15  Page No. : 4467-4473  
Title of Journal : Annual Review of Pharmacology and Toxicology  Author : Sausville Edward A.  C_Author : Yusri Elsayed  Year : 2003  Volume No. : 43  Issue No. :   Page No. : 199-231  
Title of Journal : Haematologica  Author : William Blum  C_Author : Mitch Phelps A.  Year : 2010  Volume No. : 95  Issue No. : 7  Page No. : 1097-1105  
Title of Journal : J. Med. Chem  Author : Vizirianakis Loannis S.  C_Author : Maria Chatzopoulou  Year : 2010  Volume No. : 53  Issue No. :   Page No. : 6779-6810  
Title of Journal : J. Med. Chem  Author : Vizirianakis Loannis S.  C_Author : Maria Chatzopoulou  Year : 2010  Volume No. : 53  Issue No. :   Page No. : 6779-6810  
Title of Journal : Annual Review of Pharmacology and Toxicology  Author : Sausville Edward A.  C_Author : Yusri Elsayed  Year : 2003  Volume No. : 43  Issue No. :   Page No. : 199-231  
Title of Journal : Molecular Cancer Therapeutics  Author : Rosato Roberto R.  C_Author : Almenara Jorge A.  Year : 2002  Volume No. : 1  Issue No. :   Page No. : 253-266  
Title of Journal : The British Journal of Radiology  Author : Nitta N.  C_Author : Sonoda A.  Year : 2010  Volume No. : 83  Issue No. :   Page No. : 428-432  
Title of Journal : The Oncologist  Author : Elsayed Yusri A.  C_Author : Sausville Edward A.  Year : 2001  Volume No. : 6  Issue No. :   Page No. : 517-537  
Title of Journal : Clin Cancer Res  Author : Smith Melissa E.  C_Author : Velasco Cimica  Year : 2008  Volume No. : 14  Issue No. : 2  Page No. : 523-532  
Title of Journal : Molecular pharmacology  Author : Ning Gao  C_Author : Yun Dai  Year : 2004  Volume No. : 66  Issue No. : 4  Page No. : 956-963  
Title of Journal : Thesis submitted for the degree of Doctor of Philosophy at the University of Leicester  Author : Anthony James Wilson BSc  C_Author :   Year : 2008  Volume No. :   Issue No. :   Page No. :   
Title of Journal : Oncology NEWS International  Author : Schwartz Gary K.  C_Author :   Year : 2002  Volume No. : 11  Issue No. : 5  Page No. : 1-3  
Title of Journal : Cancer Res Treat.  Author : Suzy Kim  C_Author : Hong-Gyun Wu  Year : 2005  Volume No. : 37  Issue No. : 3  Page No. : 191-195  
Title of Journal : Cell Proliferation  Author : Katrien Vermeulen  C_Author : Van Bockstaele Dirk R.  Year : 2003  Volume No. : 36  Issue No. :   Page No. : 131-149  
Title of Journal : Book-Molecular biology intelligence unit 15  Author : Blagosklonny Mikhail V.  C_Author :   Year : 2001  Volume No. : Chapter-13  Issue No. :   Page No. : 1-267  
Title of Journal : Opportunity, Challenge and Scope of Natural Products in Medicinal Chemistry  Author : Bhuwan Mishra B.  C_Author : Vinod Tiwari K.  Year : 2011  Volume No. :   Issue No. :   Page No. : 1-62  
Title of Journal : Fitoterapia  Author : Mohana kumara P.  C_Author : Sreejayan N. Priti V. Ramesha B.T. Ravikanth G. Ganeshaiah K.N. Vasudev R. Mohan J. Santhoshkumar T.R. Mishra P.D. Ram V and Uma Shaanker R.  Year : 2010  Volume No. : 81  Issue No. : 2  Page No. : 145-148  
Title of Journal : Journal of natural product\r\nhttp://dtp.nci.nih.gov  Author : Cragg Gordon M.  C_Author : Newman David J.  Year : 2003  Volume No. : 66  Issue No. :   Page No. : 1022  
Title of Journal : The FASEB Journal express article  Author : Birgit Jaschke  C_Author : Stefan Milz  Year : 2004  Volume No. :   Issue No. :   Page No. : 1-20  
Title of Journal : Research in Plant Biology  Author : Nirmala Joyce M.  C_Author : Samundeeswari A.  Year : 2011  Volume No. : 1  Issue No. : 3  Page No. : 01-14  
Title of Journal : Thesis  Author : Kelly Marie Jackman  C_Author :   Year : 2007  Volume No. :   Issue No. :   Page No. : 108  
Title of Journal : World Botanical Associates\r\nBakersfield, CA 93380-1145  Author : Richard W. Spjut  C_Author :   Year : 2010  Volume No. :   Issue No. :   Page No. : 48  
Title of Journal : Dissertation Submitted towards Doctoral Degree the Faculty of Chemistry and Pharmacy the Ludwig-Maximilians-University Munich.  Author : Ulrike Schmerwitz  C_Author :   Year : 2010  Volume No. :   Issue No. :   Page No. : 113  
Title of Journal : Anticancer Res.  Author : Wirger A.  C_Author : Perabo F.G.  Year : 2005  Volume No. : 25  Issue No. : 6  Page No. : 4341-4147  
Title of Journal : Mini Reviews in Medicinal Chemistry  Author : Wang L.M  C_Author : Ren D.M  Year : 2010  Volume No. : 10  Issue No. : 11  Page No. : 1058-1070  
Title of Journal : Int J Oncol.  Author : Sedlacek H.  C_Author : Czech J.  Year : 1996  Volume No. : 9  Issue No. : 6  Page No. : 1143-68  
Title of Journal : The Annals of Pharmacotherapy  Author : Zhai S.  C_Author : Senderowicz A.M.  Year : 2002  Volume No. : 36  Issue No. : 5  Page No. : 905-911  
Title of Journal : Thesis-Department of Pathophysiology,\r\nInstitute of Pharmaceutical Chemistry,\r\nUniversity of Vienna, Vienna, Austria  Author : Haslmayer P.  C_Author : Jager W.  Year :   Volume No. :   Issue No. :   Page No. :   
Title of Journal : Sarcoma\r\nArticle ID 64374, DOI 10.1155/SRCM/2006/64374  Author : Morris Don G.  C_Author : Bramwell Vivien H. C.  Year : 2006  Volume No. : 2006  Issue No. :   Page No. : 1-7  
Title of Journal : Journal of Global Pharma Technology\r\nAvailable Online at www.jgpt.co.in  Author : Mouli K.C.  C_Author : Vijaya T.  Year : 2009  Volume No. : 1  Issue No. : 1  Page No. : 4-18  
Title of Journal : Nat. Prod. Rep.\r\nThe Royal Society of Chemistry  Author : Newman David J.  C_Author : Cragg Gordon M.  Year : 2000  Volume No. : 17  Issue No. :   Page No. : 215-234  
Title of Journal : Planta Med  Author : Sahdeo Prasad  C_Author : Kannokarn Phromnoi  Year : 2010  Volume No. : 76  Issue No. :   Page No. : 1044-1063  
Title of Journal : Thesis- Anticancer drug development  Author : Tomaszewski Joseph E.  C_Author : Smith Adaline C.  Year :   Volume No. : chapter 21  Issue No. :   Page No. : 301-328  
Title of Journal : Thesis- University of Helsinki\r\nFaculty of Pharmacy\r\nDivision of Pharmacology and Toxicology  Author : Paivi Gruzdaitis  C_Author :   Year :   Volume No. :   Issue No. :   Page No. : 1-86, 33  
Title of Journal : Cancer Chemother Pharmacol  Author : Senderowicz AM.  C_Author :   Year : 2003  Volume No. : 52  Issue No. : 1  Page No. : 61-73  
Title of Journal : Current Opinion Pharmacol.  Author : Dai Y.  C_Author : Grant S.  Year :   Volume No. :   Issue No. :   Page No. :   
Title of Journal : Invest New Drugs  Author : Diaz Padilla I.  C_Author : Lillian Siu L.  Year : 2009  Volume No. : 27  Issue No. :   Page No. : 586-594  
Title of Journal : Springer  Author : Mohana Kumara P.  C_Author : Sebastian Zuehlke, Vaidyanathan Priti, Bheemanahally Thimmappa Ramesha, Singh Shweta, Gudasalamani Ravikanth, Ramesh Vasudeva, Thankayyan Retnabai Santhoshkumar, Michael Spiteller and Ramanan Uma Shaanker  Year :   Volume No. :   Issue No. :   Page No. :   
Title of Journal : The oncologist  Author : Adrian Senderowicz M.  C_Author :   Year : 2002  Volume No. : 7  Issue No. : 3  Page No. : 12-19  
Title of Journal : Clinical Cancer Research  Author : Geoffrey Shapiro I.  C_Author : Jeffrey Supko G.  Year : 2001  Volume No. : 7  Issue No. :   Page No. : 1590-1599  
Title of Journal : Clinical Cancer Research  Author : Ivana Gojo  C_Author : Bin Zhang  Year : 2002  Volume No. : 8  Issue No. :   Page No. : 3527-3538  
Title of Journal : Bangladesh J Pharmacol  Author : Mohammad Shoeb  C_Author :   Year : 2006  Volume No. : 1  Issue No. :   Page No. : 35-41  
Title of Journal : http://upetd.up.ac.za/thesis/available/etd-06112009-173251/unrestricted/01chapter1-3.pdf  Author : Binneman B.  C_Author :   Year : 2008  Volume No. : chapter1-3  Issue No. :   Page No. : 17-19  
Title of Journal : Clinical Cancer Research  Author : Glenn Liu  C_Author : David Gandara R.  Year : 2004  Volume No. : 10  Issue No. :   Page No. : 924-928  
Title of Journal : Clinical Cancer Research  Author : Geoffrey Shapiro I.  C_Author : Darlene Koestner A.  Year : 1999  Volume No. : 5  Issue No. :   Page No. : 2925-2938  
Title of Journal : Mol Cancer Ther  Author : Lourdes Gomez A.  C_Author : Alicia de las Pozas  Year : 2006  Volume No. : 5  Issue No. : 5  Page No. :   
Title of Journal : Cancer chemotherapy and biological response modifiers annual 20  Author : Adrian Senderowicz A.  C_Author :   Year : 2002  Volume No. : Chapter-8  Issue No. :   Page No. : 169-194  
Title of Journal : Clin Cancer Res  Author : Jennifer Brown R.  C_Author :   Year : 2005  Volume No. : 11  Issue No. : 11  Page No. :   
Title of Journal : International Journal of Pharmaceutical Sciences Review and Research  Author : Shankaracharya  C_Author : Priyamvada  Year : 2010  Volume No. : 4  Issue No. : 1  Page No. : 1-6  
Title of Journal : Current Medicinal Chemistry  Author : Peter Fischer M.  C_Author : David Lane P.  Year : 2000  Volume No. : 7  Issue No. :   Page No. : 1213-1245  
Title of Journal : Nature Reviews I Cancer  Author : Chikashi Nakanishi  C_Author : Masakazu Toi  Year : 2005  Volume No. : 5  Issue No. :   Page No. : 297-309  
Title of Journal : Oncogene  Author : Adrian Senderowicz M.  C_Author :   Year : 2003  Volume No. : 22  Issue No. :   Page No. : 6609-6620  
Title of Journal : Expert Opinion on Investigational Drugs  Author : Hui Kang Wang  C_Author :   Year : 2000  Volume No. : 9  Issue No. : 9  Page No. : 2103-2119  
Title of Journal : Molecular Cancer Therapeutics  Author : Xin Yan Pei  C_Author : Yun Dai  Year : 2004  Volume No. : 3  Issue No. : 12  Page No. : 1513-1524  
Title of Journal : International Journal of Phytomedicine  Author : Abhishek Bhanot  C_Author : Rohini Sharma  Year : 2011  Volume No. : 3  Issue No. :   Page No. : 9-26  
Title of Journal : Thesis - A dissertation presented to the graduate school of the university of florida in partial fulfillment of the requirements for the degree of doctor of philosophy university of florida  Author : Kelly Marie Jackman  C_Author :   Year : 2007  Volume No. :   Issue No. :   Page No. : 1-108  
Title of Journal : The Oncologist  Author : Dennis Mans R.A.  C_Author : Adriana B da Rocha  Year : 2000  Volume No. : 5  Issue No. :   Page No. : 185-198  
Title of Journal : Journal of Clinical Oncology  Author : Gary Schwartz K.  C_Author : David Ilson  Year : 2001  Volume No. : 19  Issue No. : 7  Page No. : 1985-1982  
Title of Journal : The Oncologist  Author : Dennis Mans R.A.  C_Author : Adriana B. Da Rocha  Year : 2000  Volume No. : 5  Issue No. :   Page No. : 185-198  
Title of Journal : Expert Opin. Ther. Targets  Author : Bharat Aggarwal B.  C_Author : Haruyo Ichikawa  Year : 2006  Volume No. : 10  Issue No. : 1  Page No. : 87-118  

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Chemical Group

Flavonoids

Reference

Title of Journal : Chinese Chemical Letters  Author : Dong Hui Yang  C_Author : Shao Qing Cai  Year : 2004  Volume No. : 14  Issue No. : 7  Page No. : 233-236  
Title of Journal : Anticancer Research  Author : Andreas Wirge  C_Author : Frank Perabo G.E.  Year : 2005  Volume No. : 25  Issue No. : 6(B)  Page No. : 4341-4347  
Title of Journal : Journal of Chemical and Pharmaceutical Research  Author : Shankaracharya.  C_Author : Priyamvada and Vidyarthi,A.S.  Year : 2010  Volume No. : 2  Issue No. : 3  Page No. : 329-337  
Title of Journal : Molecular Cancer Therapeutics  Author : Michelle Alonso  C_Author : Cristina Tamasdan  Year : 2003  Volume No. : 2  Issue No. :   Page No. : 139-150  
Title of Journal : Molecular pharmacology  Author : Yasunari Takada  C_Author : Gautam Sethi  Year : 2008  Volume No. : 73  Issue No. : 5  Page No. : 1549 - 1557  
Title of Journal : The Journal of Biological Chemistry  Author : Yasunari Takada  C_Author : Bharat Aggarwal B.  Year : 2004  Volume No. : 279,  Issue No. : 6,  Page No. : 4750 - 4759  
Title of Journal : Cancer Research  Author : Bible K.C.  C_Author : Kaufmann S.H.  Year : 1996  Volume No. : 56  Issue No. : Nov  Page No. : 4856-4861  
Title of Journal : Blood journal. Hematology Library.org  Author : Francisco Arguello  C_Author : Mark Alexander  Year : 1998  Volume No. : 91  Issue No. : 7  Page No. : 2482-2490  
Title of Journal : Journal of Pharmacological Sciences  Author : Katsuji Hattori  C_Author : Naoe Sukenobu  Year : 2003  Volume No. : 93  Issue No. :   Page No. : 69-73  
Title of Journal : Haematologica  Author : William Blum  C_Author : Mitch Phelps A.  Year : 2010  Volume No. : 95  Issue No. : 7  Page No. : 1097-1105  
Title of Journal : Current Opinion in Pharmacology  Author : Adriana B da Rocha  C_Author : Rafael Lopes M.  Year : 2001  Volume No. : 1  Issue No. :   Page No. : 364 - 369  
Title of Journal : Oncogene  Author : Adrian Senderowicz M.  C_Author :   Year : 2000  Volume No. : 19  Issue No. :   Page No. : 6600-6606  
Title of Journal : Journal of Ethnopharmacology  Author : Tomonori Unno  C_Author : Akio Sugimoto  Year : 2004  Volume No. : 93  Issue No. : 1  Page No. : 391-395  
Title of Journal : Oncogene  Author : Mirna Lechpammer  C_Author : Xiangjun Xu  Year : 2005  Volume No. : 24  Issue No. :   Page No. : 1683-1688  
Title of Journal : Ann. appl. Biol  Author : Cragg G.M.  C_Author : Newman D.J.  Year : 2003  Volume No. : 143  Issue No. :   Page No. : 127-133  
Title of Journal : Ann. appl. Biol  Author : Cragg G.M.  C_Author : Newman D.J.  Year : 2003  Volume No. : 143  Issue No. :   Page No. : 127-133  
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Toxicity

Hyperbilirubinemia and Diarrhea

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Bio-Assay

Cytotoxicity assayComputational analysis (docking)DNA Fragmentation AssayElectrophoretic Mobility Shift Assays,rnLuciferase Assay,rnJNK Assay,rnMTT Assay,rnTrypan Blue Exclusion Assay,rnClonogenic Assay.Electrophoretic Mobility Shift Assays (EMSA)Colony-forming AssaysHistone Deacetylase Assay,rnElectrophoretic mobility shift assayAnnexin V/PI AssayTUNEL Assays and Hoechst Staining.rnCaspase Assays.

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Explanation

Flavopiridol protects against inflammation by attenuating leukocyte-endothelial interaction via inhibition of cyclin-dependent kinase-9.Flavopiridol is a CDKs inhibitor & it is active against various types of tumor. Flavopiridol is reported to have cytotoxic activity against a wide range of cancer cell lines. flavopiridol has demonstrated antitumor activity against several tumor xenograftFlavopiridol is a semi-synthetic flavonoid derived from Rohitukine. It is a small molecule type drug with molecular weight 401.84. It comes under the drug category of anti neoplastic agents, glycogen phosphorylase inhibitor, growth inhibitors and protein Flavopiridol is a synthetic flavone closely related to a compound found in a plant native to India, Dysoxylum binectariferum. Currently, the drug is in Phase I and II clinical trials as an antineoplastic agent for breast, gastric, and renal cancers. The dFlavopiridol is a semisynthetic flavonoid closely related to a compound originally isolated from the stem bark of Dysoxylum binectariferum. Flavopiridol has been shown to be a potent inhibitor of cyclin-dependent kinase (CDK) 1, CDK 2, CDK 4, and CDK 7. IFlavopiridol, a synthetic flavone closely related to a compound originally isolated from the stem bark of the native Indian plant Dysoxylum binectariferum, has been found to inhibit cyclin-dependent kinases. Flavopiridol has been shown to be a potent inhiFlavopiridol is a synthetic flavone closely related to a compound originally isolated from the stem bark of the native Indian plant Dysoxylum binectariferum. It is currently undergoing Phase-I clinical trials as a potential antineoplastic agent. FlavopiriFlavopiridol inhibit potently cyclin dependent kinases (CDKs), a family of kinases which govern progression of cells through the cell cycle. Induction of G2 arrest by flavopiridol appears to be caused by both direct inhibition of CDK1 and interference witIts mechanisms of action remain incompletely defined but include targeting of cyclin dependent kinases including the CDK9/cyclin Tcomplex (preventing activation of RNA polymerase II), downregulation of Mcl-1 and other antiapoptotic proteins, induction of The mechanism of action of flavopiridol involves interfering with the phosphorylation of cyclin-dependent kinases, hampering their activation and blocking cell-cycle progression at growth phase 1 (G1) or G2.Induce cell cycle arrest at either G1/s or G2/M, concordant with the ability of favopiridol to inhibit both cdk2 and cdk1, respectively.1). The cyclin-dependent kinase (CDK) inhibitor p27 preferentially inactivates CDK complexes required for progression through the G1/S transition. Loss of p27 is associated with aggressive behavior in a variety of tumors.rn2). Directly competes with the ATShowed about a 100 fold more selectivity for CDKs compared to its activity for tyrosine kinases.First compound to inhibit Cyclin-Dependent Kinase tested in clinical trials.Possess tyrosine kinase activity and potent growth inhibitory activity against a series of breast and lung carcinoma cell lines.it is an potent inhibitor of CDK1, CDK2, and CDK4. Its anti-proliferative activity is unfolded through a variety of mechanisms besides CDK inhibition, for instance, through apoptosis, DNA interaction, and cyclin D1 decreases.Binds to the ATP-binding pocket of cyclin-dependent kinases (CDKs), and due to its indirect action reducing levels of other cyclins and cdk inhibitors, contributing to its pleiotropic effects. Flavopiridol is a potent apoptotic agent due to its ability toFlavopiridol strongly inhibits the cyclin dependent kinase activity of multiple CDKs.Flavopiridol induces cell cycle arrest and apoptosis in a variety of cell lines and is currently in phase II clinical testing. In a phase I infusional trial, postinfusional plasma concentration peaks that are compatible with enterohepatic circulation of F1). Flavopiridol binds to the ATP-binding domain of CDKs. Because of its broad inhibition of CDKs. Flavopiridol can induce cell cycle arrest and affect other cellular functions, such as transcription and apoptosis.rn2). Flavopiridol reduces transcriptionalFlavopiridol is a potent cyclin-dependent kinase inhibitor, and its use is presently under investigation for a variety of solid tumors as well as hematological cancers.Flavopiridol is a potential CDKs inhibitor.In Phase I clinical trials is scheduled to be advanced to Phase II trials against a broad range of tumors1). Potent growth inhibitor of diverse human tumor cell lines and induces apoptosis in hematopoietic cell lines derived from acute myelogenous leukemia (AML), B- and T-cell lymphomas, and multiple myeloma.rn2). Flavopiridol induced apoptosis results in parFlavopiridol effective CDKs (CDK1, CDK2, and CDK4) inhibitor.Flavopiridol is ATP-site antagonists that have completed initial phase I and phase II evaluations1). Interactions between the cyclin-dependent kinase inhibitor flavopiridol (FP) and the histone deacetylase inhibitor sodium butyrate (SB) have been examined in human leukemia cells (U937) in relation to differentiation and apoptosis.rn2). Blocked SB-relaLiver tumour-bearing rabbits treated with cisplatin-eluting GMSs plus flavopiridol, the tumour volume reduction was greater than in the other groups.1). Flavopiridol arrests cells at the transition of G2/M phases and from G1 to S phase, and also slows the progression of cell cycle through the S phase. Flavopiridol is competitive with ATP when assayed with purified cyclin/CDK complexes, and it inhibitsMolecular mechanisms of rhabdoid tumorigenesis should pave the way to developing molecularly targeted therapies for rhabdoid tumors. The essential role of cyclin D1 for rhabdoid tumorigenesis is targeting the cyclin/CDK axis could be effective in inhibitiFlavopiridol inhibits CDKs with differentiation-inducing agents such as histone deacetylase inhibitors (HDACIs) in leukemia therapy has several theoretical rationales. For example, HDACIs have been shown to be potent inducers of leukemic cell differentiatFlavopiridol was originally identified as an inhibitor of the receptor tyrosine kinases, receptor-associated kinases, and cytosolic signal transduction kinases.It selective inhibits CDK4, CDK6(Cyclin D), CDK1(Cyclin B) over CDK2(Cyclin A), CDK2(Cyclin E) Flavopiridol is a potent inhibitor of Cyclin dependent kinases CDKs via direct binding to the ATP site. it inhibits CDK 1, 2, 4, and 6 in nanomolar concentrations.Flavopiridol is a potent inhibitor of CDKs via direct binding to the ATP site. Flavopiridol inhibits CDK-1, CDK-2, CDK-4, CDK-6, and CDK-7.flavopiridol also results in the indirect inhibition of cell proliferation by reducing the expression levels of CyclFlavopiridol inhibits CDK1, CDK2 and CDK4 . Flavopiridol has the potential to inhibit the proliferation of a broad range of different types of cell lines, human tumours, leukaemias and lymphomas. Flavopiridol analogues thioflavopiridol and oxoflavopiridolFlavopiridol serves as a model for the potential antitumor agent.Flavopiridol was subsequently shown to block cell cycle progression. MDA-MB-468 breast cancer cells are released from an aphidicolin-induced block at the G1/S boundary in the presence of flaFlavopiridol is a potent inhibitor of Cyclin dependent kinases CDKs via direct binding to the ATP site.Flavopiridol semisynthetic derivative of Rohitukine, a chromane alkaloid. flavopiridol, a promising anticancer compound. Currently in Phase III clinical trials, flavopiridol is a potent inhibitor of several cyclin-dependent kinases (CDKs). Flavopiridol inSpecific inhibitor of CDK kinase activity, leading to growth arrest at both, G1/S and G2/M transition phases.Inhibiting cell cycle progression at G1 or G2 phase by interfering with the phophorylation activity of cyclindependent kinasesDecrease the activity of CDKs and induce cell cycle arrest. Cell cycle regulatory elements such as the CDK inhibitorsFlavopiridol has been found to have strong activity against multiple Cdks.1). Flavopiridol has been found to have strong activity against multiple Cdksrn2). interferes with the cell cycle at two points, it arrests the cell cycle at the G2/M phase and delays the G1 to S phase progression.rn3). flavopiridol interferes with binding Inhibit cyclin-dependent kinases (CDKs), causing cell cycle arrest and growth inhibition.A group of proteins, cyclin-dependent kinases (CDKs), that control the cell cycle, provide new targets for treating cancer. As a result, cyclin-dependent kinase inhibitors (CDKIs) represent a novel class of chemotherapeutic agents. Of these, flavopiridol,Flavopiridol strongly inhibits the cyclin-dependent kinases (cdk1, cdk2, cdk4, cdk7), with the potential to cause inhibition of cell cycle progression in G(1) and G(2) by multiple mechanisms relatable to cdk inhibition. In certain cell types, FlavopiridolFlavopiridol is an inhibitor of several CDKs and displays unique anticancer properties. flavopiridol also exhibited other features such as inducing apoptosis in many cancer cell lines, decreasing cyclin D1 concentration, and inhibiting angiogenesis. Relat1). It inhibits cyclin-dependent kinases and therefore, blocks cell cycle progression in the G1 and G2 phase. It has cytotoxic effect in a number of tumor cells lines and in vivo studies showed significant activity in hematological malignancies and solid It inhibits the kinase activity of multiple CDKs with CDK1, CDK2, CDK4. It also interferes with the phosphorylation events necessary to activate CDKs and has been shown to downregulate transcription of the cyclin D1 gene.Flavopridol possess tyrosine kinase activity and potent growth inhibitory activity against a series of breast and lung carcinoma cell lines. It also showed broad spectrum in vivo activity against human tumor xenografts in mice, either alone or in combinatFlavopiridol has a very interesting mechanism of action in that it is an inhibitor of cyclin dependent kinases (the regulators of the G2 to M transition in the cell cycle).Has been found to suppress inflammation,inhibit cyclin-dependent kinases, induce apoptosis, and modulate the immune response. The inhibition of TNF-induced inflammation by flavopiridol was associated with inhibition of NF-?B activation. This effect was meFlavopiridol has been shown to be a potent cyclin-dependent kinase inhibitor. It inhibits CDK1CDK2, and CDK4 by binding to the ATP-binding pocket of the kinase. In addition to inhibition, flavopiridol causes a decrease in cyclin D1, and it was felt that d1). Inhibit cell proliferation in various human tumour cell lines arresting cells in G1(S) and G2(M) phases. In vitro and in vivo studies have demonstrated that it inhibits several protein kinases, with the greatest activity against CDKs including CDK1, C1). Potent CDK inhibitory activity. it depletes cyclin D1 and vascular endothelial growth factor mRNA by transcriptional and posttranscriptional mechanisms, respectively.rn2). it inhibits positive elongation factor B, leading to transcription haltrn3). it1). Cell-cycle dysregulation is one of the cardinal characteristics of neoplastic cells. For this reason, small molecule inhibitors targeting cyclin-dependent kinases (CDKs), of which flavopiridol is a prototype.rn2). Flavopiridol shows several novel mechaCyclin-dependent kinases (CDKs) are core components of the cell cycle machinery that govern the transition between phases during cell cycle progression. Genes involved in cell cycle are frequently mutated in human cancer and deregulated CDK activity repreFlavopiridol was found to inhibit the epidermal growth factor receptor and protein kinase Flavopiridol was later shown to inhibit cell proliferation, flavopiridol inhibits CDK1, CDK2, CDK4, and CDK6 as well as CDK7 by competing with ATP flavopiridol is exFlavopiridol is a potent cyclin-dependent kinase inhibitor with preclinical activity against non-small cell lung cancer (NSCLC), inhibiting tumor growth in vitro and in vivo by cytostatic and cytotoxic mechanisms. Flavopiridol causes arrest at both the G1Flavopiridol is a semisynthetic flavonoid that was originally identified as a CDK inhibitor. Flavopiridol competes with ATP for binding in the active site of many CDKs, and can induce either cell cycle arrest or apoptosis, depending on the cell type, cultFlavopiridol is a synthetic flavone, derived from the plant alkaloid rohitukine, which was isolated from Dysoxylum binectariferum Hook. f. (Meliaceae). It is currently in phase I and phase II clinical trials against a broad range of tumors, including leukFlavopiridol showed most potent activity against human Xenograft. It is effectively used alone or in combination with other anticancer agents to treat a broad rangeof tumors, leukemias, lymphomas and solid tumors.Flavopiridol pan-CDK inhibitor studied in clinical trials. Flavopiridol has been shown to inhibit several tumor cell lines in vitro with its antiproliferative effects being tribute to potent inhibition of CDK1, CDK2, CDK4, and CDK6. Flavopiridol was cytosThe drug is a potent inhibitor of several cdks, including CDK1 (CDC2), CDK2, CDK4, and CDK7, because it has been shown to directly inhibit the kinase activity of CDKs from exponentially growing cells.A portion of flavopiridol interferes with binding of ATFlavopiridol,a semisynthetic flavonoid derived from an indigenous plant from India,is a broad inhibitor of cyclindependent kinases (cdk) and is being tested in clinical trials Treatment of cancer cells with flavopiridol results in a decrease in cyclins D1 Flavopiridol arrest both in G1 and G2 phases of the cell cycle. It inhibits CDK1, CDK2 and CDK4.This inhibition is irreversible and competitively blocked by ATP by binding to the ATP packets and flavopiridol decreases in the level of cyclin D1 and alteraCyclin-dependent kinases (cdks) are key regulators of orderly progression through the cell cycle and of RNA transcription. Inhibition of their activity in vitro can cause cell cycle arrest at the G1-S or G2-M boundaries.Flavopiridol is an antitumor agent in clinical trials work by blocking cell cycle progression promotes differentiation and induces apoptosis in various types of cancerous cells. Cell cycle abnormalities are the root of cancer and its progression is regulaFlavopiridol is a CDKs inhibitor with ATP antagonist activity.found to inhibit cyclin-dependent kinases, suppress inflammation, modulate the immune response and induce apoptosis, particularly in tumour cells of haematopoietic origin. In human leukaemia cells, flavopiridol-mediated cell death is through the inductionFlavopiridol is a semisynthetic flavonoid derived from rohitukine, an indigenous plant from India. Initial studies with this flavonoid revealed clear evidence of G1/S or G2/M arrest, due to loss in cdk1 and cdk2. In addition to directly inhibiting cdks, fFlavopiridol is a novel semisynthetic flavone analogue of rohitukine, a leading anticancer compound from an Indian tree. Flavopiridol inhibits most cyclin-dependent kinases and displays unique anticancer properties.Flavopiridol inhibits CDKs in multiple myeloma is a(Flavopiridol) Rohitukine alkaloid that binds tightly to the CDK at ATP binding site and broadly inhibits multiple CDKs, including CDKs 1, 2, 4/6, and 7. Flavopiridol induces perturbations in various protSynthetic flavone derived from rohitukine, Flavopiridol representing the first cyclin-dependent kinase inhibitor. The mechanism of action involves interfering with the phosphorylation of cyclin-dependent kinases and arrest cell-cycle progression at growthAbility of flavopiridol to decrease the activity of CDKs and induce cell cycle arrest. Cell cycle regulatory elements such as the CDK inhibitors p15 and p16 are altered in ALL between diagnosis and relapse, indicating that this loss of checkpoint control The mechanism of action of flavopiridol involves interference with the phosphorylation of cyclin-dependent kinases, hampering their activation, thus blocking cell cycle progression at G1 or G2. In phase I clinical trials with flavopiridol secretory diarrhAlthough its exact mechanism of action remains unknown, it is the first anticancer agent to enter clinical trials as a potent inhibitor of the cyclin-dependent kinases (CDKs). Detect no evidence of apoptosis in the peripheral lymphocytes of patients treatFlavopiridol be a potent inhibitor of cyclin-dependent kinase CDK 1, CDK 2, CDK 4 and CDK 7. It inhibits CDKs by competing with adenosine triphosphate at the nucleotide-binding site on CDKs as indicated by kinetics studies The tyrosine phosphorylation of

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