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Bio-Assay

Alkaline and neutral elution assays,

Reference

Title of Journal : Drug Metabolism And Disposition.\r\nThe American Society For Pharmacology And Experimental Therapeutics  Author : Nobumitsu Hanioka  C_Author : Shogo Ozawa  Year : 2002  Volume No. : 30  Issue No. : 4  Page No. : 391-396  
Title of Journal : Cancer Research  Author : Norimasa Kaneda  C_Author : Teruo Yokokura  Year :   Volume No. : 50  Issue No. :   Page No. : 1721-1725  
Title of Journal : Cancer Research  Author : Takehiko kunimoto  C_Author : Kazuo Nitta  Year : 1987  Volume No. : 47  Issue No. :   Page No. : 5944-5947  
Title of Journal : Cancer Research  Author : Yasuyoshi Kawato  C_Author : Masashi Animimi  Year : 1991  Volume No. : 51  Issue No. :   Page No. : 418-4191  
Title of Journal : Anticancer Research  Author : Kathleen Legarza  C_Author : Li Xi Yang  Year : 2006  Volume No. : 26  Issue No. :   Page No. : 3301-3306  
Title of Journal : British Journal of Pharmacology  Author : Tsai T.H.  C_Author : Lee C.H.  Year : 2001  Volume No. : 134  Issue No. :   Page No. : 1245-1252  

UAS,Bengaluru Language : English
Article rating from 0 people star ratingstar ratingstar ratingstar ratingstar rating Submission Date :2012-10-01
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Explanation

7-ethyl-10-hydroxycamptothecin (SN-38) plays an essential role in the mechanism of action of Camptothecin-11. SN-38, a metabolite of Camptothecin-11, shows much stronger cytotoxicity in vitro than Camptothecin -11.It shows time-dependent inhibitory activ7-ethyl-10-hydroxycamptothecin (SN38)- produces an increase in production of pro-apoptotic factors such as p53, Bax, Bcl-xl, and p-21/WAF-1 in colon cancer cells Upregulation of the pro-apoptotic proteins bax, bf11, bak, pRb2, c-jun and jun-b, and down-re

Reference

Title of Journal : Drug Metabolism And Disposition.\r\nThe American Society For Pharmacology And Experimental Therapeutics  Author : Nobumitsu Hanioka  C_Author : Shogo Ozawa  Year : 2002  Volume No. : 30  Issue No. : 4  Page No. : 391-396  
Title of Journal : Cancer Research  Author : Norimasa Kaneda  C_Author : Teruo Yokokura  Year :   Volume No. : 50  Issue No. :   Page No. : 1721-1725  
Title of Journal : Cancer Research  Author : Takehiko kunimoto  C_Author : Kazuo Nitta  Year : 1987  Volume No. : 47  Issue No. :   Page No. : 5944-5947  
Title of Journal : Cancer Research  Author : Yasuyoshi Kawato  C_Author : Masashi Animimi  Year : 1991  Volume No. : 51  Issue No. :   Page No. : 418-4191  
Title of Journal : Anticancer Research  Author : Kathleen Legarza  C_Author : Li Xi Yang  Year : 2006  Volume No. : 26  Issue No. :   Page No. : 3301-3306  
Title of Journal : British Journal of Pharmacology  Author : Tsai T.H.  C_Author : Lee C.H.  Year : 2001  Volume No. : 134  Issue No. :   Page No. : 1245-1252  

UAS,Bengaluru Language : English
Article rating from 0 people star ratingstar ratingstar ratingstar ratingstar rating Submission Date :2012-10-01
comment on or rate this article

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