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Myelosuppression,Mucositis,Diarrhea

Reference

Title of Journal : Plant Cell Rep  Author : Lorence A.  C_Author : Medina Bolivar F.  Year : 2004  Volume No. : 22  Issue No. :   Page No. : 437-441  
Title of Journal : The Cancer Handbook 1st Edition. Edited by Malcolm R. Alison ]\r\n@ 2002 John Wiley & sons. Ltd  Author : Yasuhiro Koh  C_Author : Kazuto Nishio  Year :   Volume No. : 22  Issue No. :   Page No. : 437-441  
Title of Journal : Bangladesh J Pharmacol  Author : Mohammad Shoeb  C_Author :   Year : 2006  Volume No. : 1  Issue No. :   Page No. : 35-41  
Title of Journal : Current Science  Author : Sanjay Jachak M.  C_Author : Arvind Saklani  Year : 2007  Volume No. : 92  Issue No. : 9  Page No. : 1251-1257  
Title of Journal : Current Science- Scientific Correspondence  Author :   C_Author :   Year : 2010  Volume No. : 98  Issue No. : 8  Page No. : 1006-1010  
Title of Journal : Bioorganic & Medicinal Chemistry  Author : Vandana Srivastava  C_Author : Arvind Singh Negi  Year : 2005  Volume No. : 13  Issue No. :   Page No. : 5892-5908  
Title of Journal : Indian Journal of pharmacology  Author : Dholwani K.K.  C_Author : Saluja A.K.  Year : 2008  Volume No. : 40  Issue No. : 2  Page No. : 49-58  
Title of Journal : Pure Applied Chemistry  Author : Cragg Gordon M.  C_Author : Newman David J.  Year : 2005  Volume No. : 77  Issue No. : 1  Page No. : 7-24  
Title of Journal : jnci.oxfordjournals.org  Author : Vicki Brower  C_Author :   Year : 2011  Volume No. :   Issue No. :   Page No. : 838-839  
Title of Journal : Clinical Cancer Research  Author : Rocio Garcia-Carbonero  C_Author : Jeffrey Supko G.  Year : 2002  Volume No. : 8  Issue No. :   Page No. : 641-661  
Title of Journal : The Oncologist  Author : Reginald Ewesuedo B.  C_Author : Mark Ratain J.  Year : 1997  Volume No. : 2  Issue No. :   Page No. : 359-364  
Title of Journal : Clinical Cancer Research  Author : Panayotis Pantazis  C_Author :   Year : 1995  Volume No. : 1  Issue No. :   Page No. : 1235-1244  
Title of Journal : BMC Plant Biology  Author : Alessio Valletta  C_Author : Livio Trainotti  Year : 2010  Volume No. : 10  Issue No. : 69  Page No. : 1-10  
Title of Journal : Biotechnol. Bioprocess Engg  Author : Sung Hye kim  C_Author : Byung Ki Hur  Year : 1999  Volume No. : 4  Issue No. :   Page No. : 277-280  
Title of Journal : Journal of Applied Pharmaceutical Science  Author : Xiaoning Ni  C_Author : Shiqiu Wen  Year : 2011  Volume No. : 1  Issue No. : 8  Page No. : 85-88  
Title of Journal : Records of Natural Products  Author : Ajay Namdeo G.  C_Author : Ajay Sharma  Year : 2010  Volume No. : 4  Issue No. : 1  Page No. : 64-71  
Title of Journal : Global Journal of Pharmacology  Author : Soriful Islam M.  C_Author : Mauluda Akhtar Most.  Year : 2009  Volume No. : 3  Issue No. : 2  Page No. : 99-106  
Title of Journal : Anticancer Research  Author : Kathleen Legarza  C_Author : Li Xi Yang  Year : 2006  Volume No. : 26  Issue No. :   Page No. : 3301-3306  
Title of Journal : Environmental and Molecular Mutagenesis  Author : Sabry Attia M.  C_Author : Abdul Aziz Aleisa M.  Year : 2009  Volume No. :   Issue No. :   Page No. : 1-7  
Title of Journal : Clinical Cancer Research  Author : Min Huang  C_Author : Heyong Gao  Year : 2007  Volume No. : 13  Issue No. : 4  Page No. : 1298-1307  
Title of Journal : Thesis- Dept. Medical oncology, rotterdam cancer institute (daniel den hoed Kliniek) and university hospital rotterdam  Author : Comelis johannes hendrikus gerrits  C_Author :   Year : 1997  Volume No. :   Issue No. :   Page No. :   
Title of Journal : British Journal of Pharmacology  Author : Tsai T.H.  C_Author : Lee C.H.  Year : 2001  Volume No. : 134  Issue No. :   Page No. : 1245-1252  
Title of Journal : In Vivo  Author : Kathleen Legarza  C_Author : Li Xi Yang  Year : 2005  Volume No. : 19  Issue No. :   Page No. : 283-292  
Title of Journal : Annals of Oncology  Author : Mross K.  C_Author : Richly H.  Year : 2004  Volume No. : 15  Issue No. :   Page No. : 1284-1294  
Title of Journal : Clinical Cancer Research  Author : Francis Giles J.  C_Author : Jorge Cortes E.  Year : 2002  Volume No. : 8  Issue No. :   Page No. : 2134-2141  
Title of Journal : Clinical Cancer Research  Author : Ron Mathijssen H. J.  C_Author : Robbert van Alphen J.  Year : 2001  Volume No. : 7  Issue No. :   Page No. :   
Title of Journal : Clinical Cancer Research  Author : Haydar Frangoul  C_Author : Matthew Ames M.  Year : 1999  Volume No. : 5  Issue No. :   Page No. : 3956-3962  
Title of Journal : Pharmaceutical Research  Author : Hatefi A.  C_Author : Amsden B.  Year : 2002  Volume No. : 19  Issue No. : 10  Page No. : 1389-1399  
Title of Journal : Bioorganic & Medicinal Chemistry  Author : Vandana Srivastava  C_Author : Arvind Singh Negi  Year : 2005  Volume No. : 13  Issue No. :   Page No. : 5892-5908  
Title of Journal : Brazilian Journal of Medical and Biological Research  Author : Grivicich  C_Author : Mans D.R.A.  Year : 2001  Volume No. : 34  Issue No. :   Page No. : 1087-1103  
Title of Journal : Journal of Pharmacy Research  Author : Pankaj Kumar Jangra  C_Author : Pramod Kumar Sharma  Year : 2010  Volume No. : 3  Issue No. : 12  Page No. : 3093-3096  
Title of Journal : Expert Opinion on Pharmacotherapy  Author : Tanya Ahmad  C_Author : Martin Gore  Year : 2004  Volume No. : 5  Issue No. : 11  Page No. : 2333-2340  

UAS,Bengaluru Language : English
Article rating from 0 people star ratingstar ratingstar ratingstar ratingstar rating Submission Date :2012-10-01
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Bio-Assay

Human tumor clonogenic assay

Reference

Title of Journal : Plant Cell Rep  Author : Lorence A.  C_Author : Medina Bolivar F.  Year : 2004  Volume No. : 22  Issue No. :   Page No. : 437-441  
Title of Journal : The Cancer Handbook 1st Edition. Edited by Malcolm R. Alison ]\r\n@ 2002 John Wiley & sons. Ltd  Author : Yasuhiro Koh  C_Author : Kazuto Nishio  Year :   Volume No. : 22  Issue No. :   Page No. : 437-441  
Title of Journal : Bangladesh J Pharmacol  Author : Mohammad Shoeb  C_Author :   Year : 2006  Volume No. : 1  Issue No. :   Page No. : 35-41  
Title of Journal : Current Science  Author : Sanjay Jachak M.  C_Author : Arvind Saklani  Year : 2007  Volume No. : 92  Issue No. : 9  Page No. : 1251-1257  
Title of Journal : Current Science- Scientific Correspondence  Author :   C_Author :   Year : 2010  Volume No. : 98  Issue No. : 8  Page No. : 1006-1010  
Title of Journal : Bioorganic & Medicinal Chemistry  Author : Vandana Srivastava  C_Author : Arvind Singh Negi  Year : 2005  Volume No. : 13  Issue No. :   Page No. : 5892-5908  
Title of Journal : Indian Journal of pharmacology  Author : Dholwani K.K.  C_Author : Saluja A.K.  Year : 2008  Volume No. : 40  Issue No. : 2  Page No. : 49-58  
Title of Journal : Pure Applied Chemistry  Author : Cragg Gordon M.  C_Author : Newman David J.  Year : 2005  Volume No. : 77  Issue No. : 1  Page No. : 7-24  
Title of Journal : jnci.oxfordjournals.org  Author : Vicki Brower  C_Author :   Year : 2011  Volume No. :   Issue No. :   Page No. : 838-839  
Title of Journal : Clinical Cancer Research  Author : Rocio Garcia-Carbonero  C_Author : Jeffrey Supko G.  Year : 2002  Volume No. : 8  Issue No. :   Page No. : 641-661  
Title of Journal : The Oncologist  Author : Reginald Ewesuedo B.  C_Author : Mark Ratain J.  Year : 1997  Volume No. : 2  Issue No. :   Page No. : 359-364  
Title of Journal : Clinical Cancer Research  Author : Panayotis Pantazis  C_Author :   Year : 1995  Volume No. : 1  Issue No. :   Page No. : 1235-1244  
Title of Journal : BMC Plant Biology  Author : Alessio Valletta  C_Author : Livio Trainotti  Year : 2010  Volume No. : 10  Issue No. : 69  Page No. : 1-10  
Title of Journal : Biotechnol. Bioprocess Engg  Author : Sung Hye kim  C_Author : Byung Ki Hur  Year : 1999  Volume No. : 4  Issue No. :   Page No. : 277-280  
Title of Journal : Journal of Applied Pharmaceutical Science  Author : Xiaoning Ni  C_Author : Shiqiu Wen  Year : 2011  Volume No. : 1  Issue No. : 8  Page No. : 85-88  
Title of Journal : Records of Natural Products  Author : Ajay Namdeo G.  C_Author : Ajay Sharma  Year : 2010  Volume No. : 4  Issue No. : 1  Page No. : 64-71  
Title of Journal : Global Journal of Pharmacology  Author : Soriful Islam M.  C_Author : Mauluda Akhtar Most.  Year : 2009  Volume No. : 3  Issue No. : 2  Page No. : 99-106  
Title of Journal : Anticancer Research  Author : Kathleen Legarza  C_Author : Li Xi Yang  Year : 2006  Volume No. : 26  Issue No. :   Page No. : 3301-3306  
Title of Journal : Environmental and Molecular Mutagenesis  Author : Sabry Attia M.  C_Author : Abdul Aziz Aleisa M.  Year : 2009  Volume No. :   Issue No. :   Page No. : 1-7  
Title of Journal : Clinical Cancer Research  Author : Min Huang  C_Author : Heyong Gao  Year : 2007  Volume No. : 13  Issue No. : 4  Page No. : 1298-1307  
Title of Journal : Thesis- Dept. Medical oncology, rotterdam cancer institute (daniel den hoed Kliniek) and university hospital rotterdam  Author : Comelis johannes hendrikus gerrits  C_Author :   Year : 1997  Volume No. :   Issue No. :   Page No. :   
Title of Journal : British Journal of Pharmacology  Author : Tsai T.H.  C_Author : Lee C.H.  Year : 2001  Volume No. : 134  Issue No. :   Page No. : 1245-1252  
Title of Journal : In Vivo  Author : Kathleen Legarza  C_Author : Li Xi Yang  Year : 2005  Volume No. : 19  Issue No. :   Page No. : 283-292  
Title of Journal : Annals of Oncology  Author : Mross K.  C_Author : Richly H.  Year : 2004  Volume No. : 15  Issue No. :   Page No. : 1284-1294  
Title of Journal : Clinical Cancer Research  Author : Francis Giles J.  C_Author : Jorge Cortes E.  Year : 2002  Volume No. : 8  Issue No. :   Page No. : 2134-2141  
Title of Journal : Clinical Cancer Research  Author : Ron Mathijssen H. J.  C_Author : Robbert van Alphen J.  Year : 2001  Volume No. : 7  Issue No. :   Page No. :   
Title of Journal : Clinical Cancer Research  Author : Haydar Frangoul  C_Author : Matthew Ames M.  Year : 1999  Volume No. : 5  Issue No. :   Page No. : 3956-3962  
Title of Journal : Pharmaceutical Research  Author : Hatefi A.  C_Author : Amsden B.  Year : 2002  Volume No. : 19  Issue No. : 10  Page No. : 1389-1399  
Title of Journal : Bioorganic & Medicinal Chemistry  Author : Vandana Srivastava  C_Author : Arvind Singh Negi  Year : 2005  Volume No. : 13  Issue No. :   Page No. : 5892-5908  
Title of Journal : Brazilian Journal of Medical and Biological Research  Author : Grivicich  C_Author : Mans D.R.A.  Year : 2001  Volume No. : 34  Issue No. :   Page No. : 1087-1103  
Title of Journal : Journal of Pharmacy Research  Author : Pankaj Kumar Jangra  C_Author : Pramod Kumar Sharma  Year : 2010  Volume No. : 3  Issue No. : 12  Page No. : 3093-3096  
Title of Journal : Expert Opinion on Pharmacotherapy  Author : Tanya Ahmad  C_Author : Martin Gore  Year : 2004  Volume No. : 5  Issue No. : 11  Page No. : 2333-2340  

UAS,Bengaluru Language : English
Article rating from 0 people star ratingstar ratingstar ratingstar ratingstar rating Submission Date :2012-10-01
comment on or rate this article

Explanation

Semisynthetic derivative of a plant alkaloid, camptothecin it is a Topoisomerase-I inhibitors.Topotecan revealed that the Camptothecin analog, acting as a uncompetitive inhibitor, intercalated between the upstream (-1) and downstream (+1) base pairs at the DNA cleavage site. The intercalation resulted in a shift of base pairs and displacement of tA marked increase in the total chromosomal aberrations and MN in the mouse bone marrow cells in mice treated with topotecan was observedTopotecan (TPT: 9-dimethylaminomethyl-lO-hydroxycamptothecin) is a water soluble potent camptothecin analogue with activity against various tumor types in in vitro and in vivo studies.Topotecan has been approved as a second-line agent for ovarian and small cell lung cancer, while irinotecan has been approved for metastatic colorectal carcinomait is a novel Topoisomerase-I inhibitors it shows Antileukemic activity and antiproliferative activity.Topotecan exerts its cytotoxic activity by inhibiting the enzyme topoisomerase I. Topoisomerase I forms covalent adducts with DNA, which are called covalent topoisomerase I-DNA complexes. This reaction relaxes super coiled duplex DNA, resulting in single-Topotecan is a water-soluble and potent derivatives of camptothecin. Topotecan was made water-soluble by the presence of a stable, basic side chain at carbon 9 of the A ring. It can be administered without the severe and unpredictable side effects that arTopotecan is a water-soluble analogue of camptothecin, which is a prodrug of SN-38, it is found to be the most promising anticancer agent. Shows topoisomerase I inhibitory activity. It is proved to be potent cytotoxic agents by inhibiting cellular DNA topTopotecan exhibit promissing in vitro antitumor activity in preclinical studies and a variety of target tumor types in xenograft models (Colon, Ovary, and Sarcoma). Topotecan has a non-overlapping mechanism of action from that of platinum or paclitaxel. I

Reference

Title of Journal : Plant Cell Rep  Author : Lorence A.  C_Author : Medina Bolivar F.  Year : 2004  Volume No. : 22  Issue No. :   Page No. : 437-441  
Title of Journal : The Cancer Handbook 1st Edition. Edited by Malcolm R. Alison ]\r\n@ 2002 John Wiley & sons. Ltd  Author : Yasuhiro Koh  C_Author : Kazuto Nishio  Year :   Volume No. : 22  Issue No. :   Page No. : 437-441  
Title of Journal : Bangladesh J Pharmacol  Author : Mohammad Shoeb  C_Author :   Year : 2006  Volume No. : 1  Issue No. :   Page No. : 35-41  
Title of Journal : Current Science  Author : Sanjay Jachak M.  C_Author : Arvind Saklani  Year : 2007  Volume No. : 92  Issue No. : 9  Page No. : 1251-1257  
Title of Journal : Current Science- Scientific Correspondence  Author :   C_Author :   Year : 2010  Volume No. : 98  Issue No. : 8  Page No. : 1006-1010  
Title of Journal : Bioorganic & Medicinal Chemistry  Author : Vandana Srivastava  C_Author : Arvind Singh Negi  Year : 2005  Volume No. : 13  Issue No. :   Page No. : 5892-5908  
Title of Journal : Indian Journal of pharmacology  Author : Dholwani K.K.  C_Author : Saluja A.K.  Year : 2008  Volume No. : 40  Issue No. : 2  Page No. : 49-58  
Title of Journal : Pure Applied Chemistry  Author : Cragg Gordon M.  C_Author : Newman David J.  Year : 2005  Volume No. : 77  Issue No. : 1  Page No. : 7-24  
Title of Journal : jnci.oxfordjournals.org  Author : Vicki Brower  C_Author :   Year : 2011  Volume No. :   Issue No. :   Page No. : 838-839  
Title of Journal : Clinical Cancer Research  Author : Rocio Garcia-Carbonero  C_Author : Jeffrey Supko G.  Year : 2002  Volume No. : 8  Issue No. :   Page No. : 641-661  
Title of Journal : The Oncologist  Author : Reginald Ewesuedo B.  C_Author : Mark Ratain J.  Year : 1997  Volume No. : 2  Issue No. :   Page No. : 359-364  
Title of Journal : Clinical Cancer Research  Author : Panayotis Pantazis  C_Author :   Year : 1995  Volume No. : 1  Issue No. :   Page No. : 1235-1244  
Title of Journal : BMC Plant Biology  Author : Alessio Valletta  C_Author : Livio Trainotti  Year : 2010  Volume No. : 10  Issue No. : 69  Page No. : 1-10  
Title of Journal : Biotechnol. Bioprocess Engg  Author : Sung Hye kim  C_Author : Byung Ki Hur  Year : 1999  Volume No. : 4  Issue No. :   Page No. : 277-280  
Title of Journal : Journal of Applied Pharmaceutical Science  Author : Xiaoning Ni  C_Author : Shiqiu Wen  Year : 2011  Volume No. : 1  Issue No. : 8  Page No. : 85-88  
Title of Journal : Records of Natural Products  Author : Ajay Namdeo G.  C_Author : Ajay Sharma  Year : 2010  Volume No. : 4  Issue No. : 1  Page No. : 64-71  
Title of Journal : Global Journal of Pharmacology  Author : Soriful Islam M.  C_Author : Mauluda Akhtar Most.  Year : 2009  Volume No. : 3  Issue No. : 2  Page No. : 99-106  
Title of Journal : Anticancer Research  Author : Kathleen Legarza  C_Author : Li Xi Yang  Year : 2006  Volume No. : 26  Issue No. :   Page No. : 3301-3306  
Title of Journal : Environmental and Molecular Mutagenesis  Author : Sabry Attia M.  C_Author : Abdul Aziz Aleisa M.  Year : 2009  Volume No. :   Issue No. :   Page No. : 1-7  
Title of Journal : Clinical Cancer Research  Author : Min Huang  C_Author : Heyong Gao  Year : 2007  Volume No. : 13  Issue No. : 4  Page No. : 1298-1307  
Title of Journal : Thesis- Dept. Medical oncology, rotterdam cancer institute (daniel den hoed Kliniek) and university hospital rotterdam  Author : Comelis johannes hendrikus gerrits  C_Author :   Year : 1997  Volume No. :   Issue No. :   Page No. :   
Title of Journal : British Journal of Pharmacology  Author : Tsai T.H.  C_Author : Lee C.H.  Year : 2001  Volume No. : 134  Issue No. :   Page No. : 1245-1252  
Title of Journal : In Vivo  Author : Kathleen Legarza  C_Author : Li Xi Yang  Year : 2005  Volume No. : 19  Issue No. :   Page No. : 283-292  
Title of Journal : Annals of Oncology  Author : Mross K.  C_Author : Richly H.  Year : 2004  Volume No. : 15  Issue No. :   Page No. : 1284-1294  
Title of Journal : Clinical Cancer Research  Author : Francis Giles J.  C_Author : Jorge Cortes E.  Year : 2002  Volume No. : 8  Issue No. :   Page No. : 2134-2141  
Title of Journal : Clinical Cancer Research  Author : Ron Mathijssen H. J.  C_Author : Robbert van Alphen J.  Year : 2001  Volume No. : 7  Issue No. :   Page No. :   
Title of Journal : Clinical Cancer Research  Author : Haydar Frangoul  C_Author : Matthew Ames M.  Year : 1999  Volume No. : 5  Issue No. :   Page No. : 3956-3962  
Title of Journal : Pharmaceutical Research  Author : Hatefi A.  C_Author : Amsden B.  Year : 2002  Volume No. : 19  Issue No. : 10  Page No. : 1389-1399  
Title of Journal : Bioorganic & Medicinal Chemistry  Author : Vandana Srivastava  C_Author : Arvind Singh Negi  Year : 2005  Volume No. : 13  Issue No. :   Page No. : 5892-5908  
Title of Journal : Brazilian Journal of Medical and Biological Research  Author : Grivicich  C_Author : Mans D.R.A.  Year : 2001  Volume No. : 34  Issue No. :   Page No. : 1087-1103  
Title of Journal : Journal of Pharmacy Research  Author : Pankaj Kumar Jangra  C_Author : Pramod Kumar Sharma  Year : 2010  Volume No. : 3  Issue No. : 12  Page No. : 3093-3096  
Title of Journal : Expert Opinion on Pharmacotherapy  Author : Tanya Ahmad  C_Author : Martin Gore  Year : 2004  Volume No. : 5  Issue No. : 11  Page No. : 2333-2340  

UAS,Bengaluru Language : English
Article rating from 0 people star ratingstar ratingstar ratingstar ratingstar rating Submission Date :2012-10-01
comment on or rate this article

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