Asiatic acid exhibited positive interactions with tobramycin, indicating that natural products, reduce the tolerance of P. aeruginosa biofilm bacteria to antibiotics. Moreover, when P. aeruginosa biofilms were grown in the presence of 10 _g/ml of asiatic acid, they became more susceptible to 10 _g/ml of ciprofloxacin.
Title of Journal : Antimicrobial Agents and Chemotherapy Author : Eliane Garo C_Author : Gary Eldridge R. Year : 2007 Volume No. : 51 Issue No. : 5 Page No. : 1813-1817